Biochemical Role of Crucial TonB Protein in Bacterial Iron Transport and Pathogenesis

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words only definitions & notes
  1. Yersinia pestis
    a bacillus bacterium that causes the plague
    Gram-negative bacteria can cause diseases such as Escherichia coli, Salmonella typhi, Yersinia pestis, Vibrio cholera, Brucella abortus, Neisseria meningitidis cause many diseases and clinical conditions; they all transport iron by the same mechanism that depends on the actions of TonB.
  2. Brucella
    an aerobic Gram-negative coccobacillus that causes brucellosis; can be used as a bioweapon
    Gram-negative bacteria can cause diseases such as Escherichia coli, Salmonella typhi, Yersinia pestis, Vibrio cholera, Brucella abortus, Neisseria meningitidis cause many diseases and clinical conditions; they all transport iron by the same mechanism that depends on the actions of TonB.
  3. Salmonella typhi
    a form of salmonella that causes typhoid fever
    Gram-negative bacteria can cause diseases such as Escherichia coli, Salmonella typhi, Yersinia pestis, Vibrio cholera, Brucella abortus, Neisseria meningitidis cause many diseases and clinical conditions; they all transport iron by the same mechanism that depends on the actions of TonB.
  4. abortus
    a human fetus whose weight is less than 0.5 kilogram when removed or expelled from the mother's body
    Gram-negative bacteria can cause diseases such as Escherichia coli, Salmonella typhi, Yersinia pestis, Vibrio cholera, Brucella abortus, Neisseria meningitidis cause many diseases and clinical conditions; they all transport iron by the same mechanism that depends on the actions of TonB.
  5. Escherichia coli
    a species of bacterium normally present in intestinal tract of humans and other animals
    Gram-negative bacteria can cause diseases such as Escherichia coli, Salmonella typhi, Yersinia pestis, Vibrio cholera, Brucella abortus, Neisseria meningitidis cause many diseases and clinical conditions; they all transport iron by the same mechanism that depends on the actions of TonB.
  6. escherichia
    a genus of enteric bacteria
    Gram-negative bacteria can cause diseases such as Escherichia coli, Salmonella typhi, Yersinia pestis, Vibrio cholera, Brucella abortus, Neisseria meningitidis cause many diseases and clinical conditions; they all transport iron by the same mechanism that depends on the actions of TonB.
  7. pathogen
    any disease-producing agent
    "Host proteins defend cells and tissues by sequestering the metal, and successful pathogens overcome this barrier and capture the iron.
  8. pestis
    a serious (sometimes fatal) infection of rodents caused by Yersinia pestis and accidentally transmitted to humans by the bite of a flea that has bitten an infected animal
    Gram-negative bacteria can cause diseases such as Escherichia coli, Salmonella typhi, Yersinia pestis, Vibrio cholera, Brucella abortus, Neisseria meningitidis cause many diseases and clinical conditions; they all transport iron by the same mechanism that depends on the actions of TonB.
  9. electrochemical
    of or involving electrochemistry
    He and his colleagues found that the cellular electrochemical forces put TonB in a spinning motion that provides the energy and physical mechanism to enable iron uptake into the cell.
  10. vibrio
    curved rodlike motile bacterium
    Gram-negative bacteria can cause diseases such as Escherichia coli, Salmonella typhi, Yersinia pestis, Vibrio cholera, Brucella abortus, Neisseria meningitidis cause many diseases and clinical conditions; they all transport iron by the same mechanism that depends on the actions of TonB.
  11. sequester
    keep away from others
    "Host proteins defend cells and tissues by sequestering the metal, and successful pathogens overcome this barrier and capture the iron.
  12. salmonella
    bacteria that can cause typhoid fever and food poisoning
    Gram-negative bacteria can cause diseases such as Escherichia coli, Salmonella typhi, Yersinia pestis, Vibrio cholera, Brucella abortus, Neisseria meningitidis cause many diseases and clinical conditions; they all transport iron by the same mechanism that depends on the actions of TonB.
  13. meningitis
    infectious disease characterized by inflammation of the meninges (the tissues that surround the brain or spinal cord) usually caused by a bacterial infection; symptoms include headache and stiff neck and fever and nausea
    A Kansas State University-led study has discovered the role of a protein in bacteria that cause a wide variety of diseases, including typhoid fever, plague, meningitis and dysentery.
  14. protein
    an organic compound essential to living cells
    A Kansas State University-led study has discovered the role of a protein in bacteria that cause a wide variety of diseases, including typhoid fever, plague, meningitis and dysentery.
  15. membrane
    a sheet of tissue that lines or connects organs or cells
    Their study, "Energy-dependent motion of TonB in the Gram-negative bacterial inner membrane," appears in the journal Proceedings of the National Academy of Sciences, or PNAS.
  16. mechanism
    device consisting of a piece of machinery
    But the iron transport mechanisms of pathogenic organisms are not well understood."
  17. dysentery
    an infection of the intestines marked by severe diarrhea
    A Kansas State University-led study has discovered the role of a protein in bacteria that cause a wide variety of diseases, including typhoid fever, plague, meningitis and dysentery.
  18. negative
    characterized by denial or opposition or resistance
    Their study, "Energy-dependent motion of TonB in the Gram-negative bacterial inner membrane," appears in the journal Proceedings of the National Academy of Sciences, or PNAS.
  19. colleague
    an associate that one works with
    -------------------------------------------------------------------------------- Share This: 9 Phillip E. Klebba, professor and head of the department of biochemistry and molecular biophysics, made the findings with two colleagues in the department: Lorne D. Jordan, doctoral candidate, Manhattan, and Salete M. Newton, research professor.
  20. infectious
    relating to the invasion of germs that cause disease
    The iron acquisition systems of bacteria, however, contribute to infectious diseases.
  21. acquisition
    something gained
    The iron acquisition systems of bacteria, however, contribute to infectious diseases.
  22. cholera
    a contagious disease that affects the small intestine
    Gram-negative bacteria can cause diseases such as Escherichia coli, Salmonella typhi, Yersinia pestis, Vibrio cholera, Brucella abortus, Neisseria meningitidis cause many diseases and clinical conditions; they all transport iron by the same mechanism that depends on the actions of TonB.
  23. biological
    pertaining to life and living things
    Both animals and bacteria require iron for biological processes like energy generation and DNA, Klebba said.
  24. Newton
    English mathematician and physicist
    -------------------------------------------------------------------------------- Share This: 9 Phillip E. Klebba, professor and head of the department of biochemistry and molecular biophysics, made the findings with two colleagues in the department: Lorne D. Jordan, doctoral candidate, Manhattan, and Salete M. Newton, research professor.
Created on 七月 11, 2013

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