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Biochemists Discover New Mechanism in Ribosome Formation: Protein Controls Synchronized Transport of Ribosome Factors

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  1. eukaryote
    an organism of one or more cells with membrane-bound nuclei
    In an interdisciplinary approach, the Heidelberg scientists, along with colleagues from Switzerland and Japan, describe a heretofore uncharacterised protein that plays a specific role in ribosome assembly in eukaryotes, organisms whose cells contain a cell nucleus.
  2. ribosome
    a particle in a cell that helps synthesize proteins
    A new mechanism in the formation of ribosomes has been discovered by researchers from the Heidelberg University Biochemistry Center.
  3. macromolecular
    relating to or consisting of or characterized by macromolecules
    Ribosomes, the protein factories of the cell, are macromolecular complexes of ribonucleic acids (RNA) and ribosomal proteins (r-proteins) that are organised in a highly complicated three-dimensional nanostructure.
  4. cell nucleus
    a part of the cell containing DNA and RNA and responsible for growth and reproduction
    In an interdisciplinary approach, the Heidelberg scientists, along with colleagues from Switzerland and Japan, describe a heretofore uncharacterised protein that plays a specific role in ribosome assembly in eukaryotes, organisms whose cells contain a cell nucleus.
  5. synchronise
    happen at the same time
    This factor is called Symportin1, for synchronised import.
  6. cytoplasm
    the substance inside a cell, not including the nucleus
    Therefore, the r-proteins needed for ribosome formation must travel from the cytoplasm of the cell to a site in the nucleus where the ribosomes are assembled.
  7. interdisciplinary
    drawing from two or more fields of study
    In an interdisciplinary approach, the Heidelberg scientists, along with colleagues from Switzerland and Japan, describe a heretofore uncharacterised protein that plays a specific role in ribosome assembly in eukaryotes, organisms whose cells contain a cell nucleus.
  8. protein
    an organic compound essential to living cells
    In an interdisciplinary approach, the Heidelberg scientists, along with colleagues from Switzerland and Japan, describe a heretofore uncharacterised protein that plays a specific role in ribosome assembly in eukaryotes, organisms whose cells contain a cell nucleus.
  9. crystallisation
    the formation of crystals
    The study took advantage of the Biochemistry Center's crystallisation platform and the research received support from the Cluster of Excellence "CellNetworks" of Heidelberg University.
  10. dimensional
    relating to coordinates that determine a position in space
    Ribosomes, the protein factories of the cell, are macromolecular complexes of ribonucleic acids (RNA) and ribosomal proteins (r-proteins) that are organised in a highly complicated three-dimensional nanostructure.
  11. dieter
    a person who diets
    "It employs a familiar logistical concept from every day life, like picking up a hitchhiker or sharing a taxi with someone headed for the same destination," says Dr. Gert Bange of the BZH, lead author of the study together with Dr. Dieter Kressler (now of Fribourg University).
  12. nucleus
    a part of the cell responsible for growth and reproduction
    In an interdisciplinary approach, the Heidelberg scientists, along with colleagues from Switzerland and Japan, describe a heretofore uncharacterised protein that plays a specific role in ribosome assembly in eukaryotes, organisms whose cells contain a cell nucleus.
  13. RNA
    a nucleic acid that helps synthesize proteins and transmit genetic data
    Ribosomes, the protein factories of the cell, are macromolecular complexes of ribonucleic acids (RNA) and ribosomal proteins (r-proteins) that are organised in a highly complicated three-dimensional nanostructure.
  14. Osaka
    port city on southern Honshu on Osaka Bay
    The researchers from Heidelberg University and the University of Fribourg (Switzerland) collaborated closely with colleagues from Osaka University in Japan on the research.
  15. synthesis
    the combination of ideas into a complex whole
    This protein makes sure that specific factors required for ribosome synthesis are transported together, like hitchhikers, into the nucleus to the site of assembly.
  16. predominantly
    much greater in number or influence
    In eukaryotes, new ribosomes are formed predominantly in the cell nucleus.
Created on 七月 11, 2013

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